With quotes from major figureheads like Thomas Jefferson, George W. Bush and Osama Bin Laden, Bill Maher, with a Jewish-Catholic background, sets out to prove that having faith and seeking directions from God is basically ridiculous and may be due to a neurotic disorder. Interviewing Christians, Catholics, Jews, Muslims, Mormons, scientists, gays, and atheists, he cites that the number of non-believers is increasing in North America.